Saline solution: My eyes are extremely delicate eyelash-hoarding flowers, so generic saline feels like I upended a bucket of sand into my eyes. And then rubbed them until I saw purple lights (which incidentally, I used to do in my closet as a child. Which explains a lot.) Since I can’t be like my husband, who gets away with the $12 boxes of contacts and can wear the same pair for months using generic saline, I have to pony up for the real thing.
Mountain Dew: For awhile I was trying to find every little way to save money, so I bought our grocery store’s version of Mountain Dew. It was called something like “Mountain Mist,” and it was awful. Nothing tastes like Mountain Dew except for Mountain Dew. (I can also tell the difference between Coke and Pepsi every single time (preferring Coke), so I’m the priss who delighted in doing the Pepsi Taste Test Challenges in the 1980s, gleefully choosing Coke every single time.)
Girl stuff: I think you know what I mean. Dear God, not worth it.
Band-aids: We currently have a box of generic bandages and they work OK, if by OK I mean “needing to replace them every five minutes because the adhesive is made of a combination of oil and something else so slippery it has no adhesive qualities whatsoever.”
Razors: I used to get the razor that came with a built-in layer of shaving cream and it was awesome. It was also really, really freaking expensive. So instead of taking a step down and buying a slightly cheaper razor, I overcompensated and bought generic razors. And that is why my legs feel like sandpaper even though I just shaved yesterday, I swear to God.
Potato chips: Our grocery store used to sell a generic brand of potato chips called “Super Crunch.” They were actually really good, but then they suddenly stopped selling them and replaced them with something called “Krunchers.” (The “K” means Savings!) And surprise! The buffalo wing-flavored chips were amazing. And they were only 97 cents a bag. But then we realized that was just a one-time sale price and the regular price was $3.97. Which in my book is no longer generic, so I may as well buy the Cheddar and Sour Cream Ruffles I love anyway.
Lint rollers: We lint roll our furniture at least twice a week (and Abby too, who comes galloping out of nowhere once she hears the ripping of the paper off the roll, and meows belligerently at you until you run the lint roller down her back while she drools in bliss on the comforter). The name-brand lint rollers are kind of pricey, but we tried the generic version once and ended up needing five times as many sheets to get the job done.

Less talking, more lint rolling!
How about you? What items won’t you buy as generics?